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【输血纵览】小儿肿瘤患者输注病原灭活技术处理的红细胞的安全性和有效性

分类:输血管理   来源:   日期:2019-03-26 11:01:12

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病原体减少技术(PRT)是目前常用的灭活血小板和血浆中多种病原体的技术。然而,由于红细胞的脆弱性和吸收特性,全血或红细胞的PRT并没有得到很好的发展。为了研究PRT处理过的全血中的红细胞的安全性和有效性,研究人员在输注ɣ射线照射的红细胞(N=35)或PRT处理的全血的红细胞(核黄素和紫外线)(N=35)后,对各种癌症患儿(中位年龄为3.1岁)进行了30天的随访。血红蛋白浓度的增加在两组中相似。两组输血相关不良反应均较轻,发生率均为5.7%。PRT可能是一种合适的替代ɣ射线照射的方法,以确保那些输血相关的移植物抗宿主病的高风险者红细胞输注的安全性。需要进行更大规模的研究,以进一步确保经PRT处理的红细胞的安全性和临床有效性。

 

原文:Pathogen reduction technology (PRT) is now commonly used to inactivate many types of pathogens in platelets and plasma. PRT for whole blood or RBCs, however, is not as well developed due to the fragility and absorption characteristics of RBCs. In order to investigate the safely and effectiveness of RBCs from PRT treated whole blood, researchers followed pediatric patients (median age, 3.1) with various cancers for 30 days after transfusion with either ɣ-irradiated RBCs (N=35) or RBCs from PRT treated whole blood (riboflavin and UV light) (N=35). Increases in hemoglobin concentration were similar in both groups. All transfusion associated adverse events were mild and rates were the same in both groups (5.7%). PRT may be a suitable alternative to ɣ-irradiation for ensuring RBCs are safe for those at risk for transfusion-associated graft-vs-host disease. Larger studies are needed to further ensure the safety and clinical effectiveness of PRT-treated RBCs.

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